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The solution structure of the K63-Ub2:tUIMs complex

Solution NMR
PDB entry 2rr9 coloured by chain, ensemble of 20 models, front view.
PDB entry 2rr9 coloured by chain, ensemble of 20 models, side view.
PDB entry 2rr9 coloured by chain, ensemble of 20 models, top view.
Source organism: Homo sapiens
Assembly composition:
hetero trimer (preferred)
Entry contents: 2 distinct polypeptide molecules

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Assemblies

Assembly 1 (preferred)
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Assembly Name: BRCA1-A complex subunit RAP80 and Ubiquitin
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Multimeric state: hetero trimer
Accessible surface area: 12631.14 Å2
Buried surface area: 2167.03 Å2
Dissociation area: 1,083.51 Å2
Dissociation energy (ΔGdiss): -1.95 kcal/mol
Dissociation entropy (TΔSdiss): 20.61 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-143440

Macromolecules

Ubiquitin
Chains: A, B
Length: 76 amino acids
Theoretical weight: 8.58 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P0CG48 (Residues: 609-684; Coverage: 11%)
Gene name: UBC
Pfam: Ubiquitin family
InterPro:
CATH: Phosphatidylinositol 3-kinase Catalytic Subunit; Chain A, domain 1
Ubiquitin in PDB entry 2rr9, assembly 1, front view.
Ubiquitin in PDB entry 2rr9, assembly 1, side view.
Ubiquitin in PDB entry 2rr9, assembly 1, top view.
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BRCA1-A complex subunit RAP80
Chain: C
Length: 46 amino acids
Theoretical weight: 5.32 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q96RL1 (Residues: 79-124; Coverage: 6%)
Gene names: RAP80, RXRIP110, UIMC1
Pfam: RAP80 N-terminal ubiquitin interaction motif
InterPro:
BRCA1-A complex subunit RAP80 in PDB entry 2rr9, assembly 1, front view.
BRCA1-A complex subunit RAP80 in PDB entry 2rr9, assembly 1, side view.
BRCA1-A complex subunit RAP80 in PDB entry 2rr9, assembly 1, top view.
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