› 2rr4

Solution NMR

Complex structure of the zf-CW domain and the H3K4me3 peptide

Released:
DOI: 10.2210/pdb2rr4/pdb
PDB entry 2rr4 coloured by chain, ensemble of 20 models, front view.
PDB entry 2rr4 coloured by chain, ensemble of 20 models, side view.
PDB entry 2rr4 coloured by chain, ensemble of 20 models, top view.
Source organism: Homo sapiens
Primary publication:
Structural insight into the zinc finger CW domain as a histone modification reader.
He F, Umehara T, Saito K, Harada T, Watanabe S, Yabuki T, Kigawa T, Takahashi M, Kuwasako K, Tsuda K, Matsuda T, Aoki M, Seki E, Kobayashi N, Güntert P, Yokoyama S, Muto Y
Structure 18 1127-39 (2010)
PMID: 20826339

Function and Biology Details

Biochemical function:
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-159444 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Zinc finger CW-type PWWP domain protein 1 Chain: A
Molecule details ›
Chain: A
Length: 69 amino acids
Theoretical weight: 7.65 KDa
Source organism: Homo sapiens
Expression system: cell free synthsis
UniProt:
  • Canonical: Q9H0M4 (Residues: 246-307; Coverage: 10%)
Gene name: ZCWPW1
Sequence domains: CW-type Zinc Finger
Structure domains: Herpes Virus-1
Histone H3.1 Chain: B
Molecule details ›
Chain: B
Length: 10 amino acids
Theoretical weight: 1.19 KDa
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
  • Canonical: P68431 (Residues: 2-11; Coverage: 7%)
Gene names: H3C1, H3C10, H3C11, H3C12, H3C2, H3C3, H3C4, H3C6, H3C7, H3C8, H3FA, H3FB, H3FC HIST1H3C, H3FD, H3FF, H3FH, H3FI, H3FJ, H3FK, H3FL, HIST1H3A, HIST1H3B, HIST1H3D, HIST1H3E, HIST1H3F, HIST1H3G, HIST1H3H, HIST1H3I, HIST1H3J

Ligands and Environments

1 bound ligand:
Ligand ZN 1 x ZN
1 modified residue:
Ligand M3L 1 x M3L

Experiments and Validation Details

Entry percentile scores
Refinement method: torsion angle dynamics, simulated annealing
Expression system: Not provided

Quick links

Citations

20 review citations

Perceiving the epigenetic landscape through histone readers.
Musselman et al. (2012)
19 more

5 mentions without citation

Structure-function analysis reveals a novel mechanism for regulation of histone demethylase LSD2/AOF1/KDM1b.
Zhang et al. (2013)
4 more