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The NMR structure of the submillisecond folding intermediate of the Thermus thermophilus ribonuclease H

Source organism: Thermus thermophilus HB8
Biochemical function: RNA-DNA hybrid ribonuclease activity
Biological process: not assigned
Cellular component: not assigned

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EC 3.1.26.4: Ribonuclease H

Reaction catalysed:
Endonucleolytic cleavage to 5'-phosphomonoester.
Systematic name:
-
Alternative Name(s):
  • Calf thymus ribonuclease H
  • Endoribonuclease H
  • Endoribonuclease H (calf thymus)
  • Hybrid nuclease
  • Hybrid ribonuclease
  • Hybridase
  • Hybridase (ribonuclease H)
  • RNA*DNA hybrid ribonucleotidohydrolase
  • RNase H

GO terms

Biochemical function:
Biological process:
  • not assigned
Cellular component:
  • not assigned

Sequence family

Pfam Protein family (Pfam)
PF00075
Domain description: RNase H
Occurring in:
  1. Ribonuclease H
The deposited structure of PDB entry 2rpi contains 1 copy of Pfam domain PF00075 (RNase H) in Ribonuclease H. Showing 1 copy in chain A.

InterPro InterPro annotations
IPR002156
Domain description: Ribonuclease H domain
Occurring in:
  1. Ribonuclease H
IPR022892
Domain description: Ribonuclease HI
Occurring in:
  1. Ribonuclease H
IPR012337
Domain description: Ribonuclease H-like superfamily
Occurring in:
  1. Ribonuclease H
IPR036397
Domain description: Ribonuclease H superfamily
Occurring in:
  1. Ribonuclease H

Structure domain

CATH CATH domain
3.30.420.10
Class: Alpha Beta
Architecture: 2-Layer Sandwich
Topology: Nucleotidyltransferase; domain 5
Homology: Ribonuclease H-like superfamily/Ribonuclease H
Occurring in:
  1. Ribonuclease H
The deposited structure of PDB entry 2rpi contains 1 copy of CATH domain 3.30.420.10 (Nucleotidyltransferase; domain 5) in Ribonuclease H. Showing 1 copy in chain A.

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