› 2rc9

X-ray diffraction
1.96Å resolution

Crystal structure of the NR3A ligand binding core complex with ACPC at 1.96 Angstrom resolution

Released:
DOI: 10.2210/pdb2rc9/pdb
PDB entry 2rc9 coloured by chain, front view.
PDB entry 2rc9 coloured by chain, side view.
PDB entry 2rc9 coloured by chain, top view.
Source organism: Rattus norvegicus
Primary publication:
Molecular mechanism of ligand recognition by NR3 subtype glutamate receptors.
Yao Y, Harrison CB, Freddolino PL, Schulten K, Mayer ML
EMBO J 27 2158-70 (2008)
PMID: 18636091

Function and Biology Details

Biochemical function:
Biological process:
  • not assigned
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-193094 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Glutamate receptor ionotropic, NMDA 3A Chains: A, B
Molecule details ›
Chains: A, B
Length: 294 amino acids
Theoretical weight: 32.94 KDa
Source organism: Rattus norvegicus
Expression system: Escherichia coli
UniProt:
  • Canonical: Q9R1M7 (Residues: 511-660, 776-915; Coverage: 26%)
Gene name: Grin3a
Sequence domains:
Structure domains: Periplasmic binding protein-like II

Ligands and Environments

1 bound ligand:
Ligand 1AC 2 x 1AC
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 22-ID
Spacegroup: P21
Unit cell:
a: 49.675Å b: 103.552Å c: 59.798Å
α: 90° β: 95.04° γ: 90°
R-values:
R R work R free
0.159 0.156 0.211
Expression system: Escherichia coli

Quick links

Citations

20 review citations

Glutamate receptor ion channels: structure, regulation, and function.
Traynelis et al. (2010)
19 more

1 mention without citation

Molecular mechanism of ligand recognition by NR3 subtype glutamate receptors.
Yao et al. (2008)