2rax

X-ray diffraction
3.3Å resolution

Crystal structure of Borealin (20-78) bound to Survivin (1-120)

Released:
Source organism: Homo sapiens

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Baculoviral IAP repeat-containing protein 5 Chains: A, E, X
Molecule details ›
Chains: A, E, X
Length: 123 amino acids
Theoretical weight: 14.12 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: O15392 (Residues: 1-120; Coverage: 85%)
Gene names: API4, BIRC5, IAP4
Sequence domains: Inhibitor of Apoptosis domain
Structure domains: Inhibitor Of Apoptosis Protein (2mihbC-IAP-1); Chain A
Borealin Chains: B, F, Y
Molecule details ›
Chains: B, F, Y
Length: 68 amino acids
Theoretical weight: 8.27 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q53HL2 (Residues: 20-78; Coverage: 21%)
Gene names: CDCA8, PESCRG3
Sequence domains: Nbl1 / Borealin N terminal

Ligands and Environments

1 bound ligand:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SSRL BEAMLINE BL9-2
Spacegroup: I4122
Unit cell:
a: 145.521Å b: 145.521Å c: 217.429Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.239 0.236 0.284
Expression system: Escherichia coli