› 2r1q

X-ray diffraction
2.5Å resolution

Crystal Structure of Iodinated Human Saposin D in Space Group C2221

Released:
DOI: 10.2210/pdb2r1q/pdb
PDB entry 2r1q coloured by chain, front view.
PDB entry 2r1q coloured by chain, side view.
PDB entry 2r1q coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Crystal structures of human saposins C andD: implications for lipid recognition and membrane interactions.
Rossmann M, Schultz-Heienbrok R, Behlke J, Remmel N, Alings C, Sandhoff K, Saenger W, Maier T
Structure 16 809-17 (2008)
PMID: 18462685

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-139657 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Saposin-D Chain: A
Molecule details ›
Chain: A
Length: 85 amino acids
Theoretical weight: 9.78 KDa
Source organism: Homo sapiens
Expression system: Komagataella pastoris
UniProt:
  • Canonical: P07602 (Residues: 407-484; Coverage: 15%)
Gene names: GLBA, PSAP, SAP1
Sequence domains:
Structure domains: Saposin-like

Ligands and Environments

No bound ligands
1 modified residue:
Ligand IYR 1 x IYR

Experiments and Validation Details

Entry percentile scores
X-ray source: BESSY BEAMLINE 14.1
Spacegroup: C2221
Unit cell:
a: 40.465Å b: 74.879Å c: 66.791Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.25 0.248 0.278
Expression system: Komagataella pastoris

Quick links

Citations

14 review citations

Lysosomal degradation of membrane lipids.
Kolter et al. (2010)
13 more

2 mentions without citation

How α-Helical Motifs Form Functionally Diverse Lipid-Binding Compartments.
Malinina et al. (2017)
1 more