2quk

X-ray diffraction
2.8Å resolution

Crystal structures of human tryptophanyl-tRNA synthetase in complex with ATP(putative)

Released:

Function and Biology Details

Reaction catalysed:
ATP + L-tryptophan + tRNA(Trp) = AMP + diphosphate + L-tryptophyl-tRNA(Trp)
Biochemical function:
Biological process:
Cellular component:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Tryptophan--tRNA ligase, cytoplasmic Chain: A
Molecule details ›
Chain: A
Length: 477 amino acids
Theoretical weight: 54.06 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P23381 (Residues: 1-471; Coverage: 100%)
Gene names: IFI53, WARS, WARS1, WRS
Sequence domains:
Structure domains:

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: PHOTON FACTORY BEAMLINE BL-5A
Spacegroup: P622
Unit cell:
a: 235.6Å b: 235.6Å c: 48.8Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.267 0.267 0.29
Expression system: Escherichia coli BL21(DE3)