PDBe 2quh

X-ray diffraction
2.4Å resolution

Crystal structures of human tryptophanyl-tRNA synthetase in complex with Trp

Released:

Function and Biology Details

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Tryptophan--tRNA ligase, cytoplasmic Chains: A, B
Molecule details ›
Chains: A, B
Length: 477 amino acids
Theoretical weight: 54.06 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P23381 (Residues: 1-471; Coverage: 100%)
Gene names: IFI53, WARS, WRS
Sequence domains:
Structure domains:

Ligands and Environments

1 bound ligand:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: PHOTON FACTORY BEAMLINE BL-5A
Spacegroup: P43212
Unit cell:
a: 79.9Å b: 79.9Å c: 382.3Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.207 0.207 0.233
Expression system: Escherichia coli BL21(DE3)