PDBe 2qtz

X-ray diffraction
1.9Å resolution

Crystal Structure of the NADP+-bound FAD-containing FNR-like Module of Human Methionine Synthase Reductase

Released:

Function and Biology Details

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Methionine synthase reductase Chain: A
Molecule details ›
Chain: A
Length: 539 amino acids
Theoretical weight: 60.06 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q9UBK8 (Residues: 165-698; Coverage: 77%)
Gene name: MTRR
Sequence domains:
Structure domains:

Ligands and Environments


Cofactor: Ligand NAP 1 x NAP

Cofactor: Ligand FAD 1 x FAD
No bound ligands

1 modified residue:

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF BEAMLINE ID14-3
Spacegroup: P21
Unit cell:
a: 51.784Å b: 67.235Å c: 78.615Å
α: 90° β: 106.91° γ: 90°
R-values:
R R work R free
0.177 0.175 0.211
Expression system: Escherichia coli BL21(DE3)