Function and Biology Details
Reaction catalysed:
2 [methionine synthase]-methylcob(III)alamin + 2 S-adenosyl-L-homocysteine + NADP(+) = 2 [methionine synthase]-cob(II)alamin + NADPH + 2 S-adenosyl-L-methionine
Biochemical function:
Biological process:
- not assigned
Cellular component:
- not assigned
Sequence domains:
- Flavoprotein pyridine nucleotide cytochrome reductase
- Ferredoxin-NADP reductase (FNR), nucleotide-binding domain
- Oxidoreductase FAD/NAD(P)-binding
- FAD-binding domain, ferredoxin reductase-type
- Sulfite reductase [NADPH] flavoprotein alpha-component-like, FAD-binding
- NADPH-cytochrome p450 reductase, FAD-binding, alpha-helical domain superfamily
- Riboflavin synthase-like beta-barrel
Structure analysis Details
Assembly composition:
monomeric (preferred)
Assembly name:
Methionine synthase reductase (preferred)
PDBe Complex ID:
PDB-CPX-193654 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Methionine synthase reductase
Molecule details ›
Chain: A
Length: 539 amino acids
Theoretical weight: 60.07 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
Sequence domains:
Structure domains:
Length: 539 amino acids
Theoretical weight: 60.07 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
- Canonical:
Q9UBK8 (Residues: 165-698; Coverage: 77%)
Sequence domains:
Structure domains:
