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Human C3c in complex with the inhibitor compstatin

X-ray diffraction
2.4Å resolution
PDB entry 2qki coloured by chain, front view.
PDB entry 2qki coloured by chain, side view.
PDB entry 2qki coloured by chain, top view.
Source organism: Homo sapiens
Assembly composition:
hetero tetramer (preferred)
Entry contents: 4 distinct polypeptide molecules

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Complement C3d fragment and peptide
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Multimeric state: hetero tetramer
Accessible surface area: 50777.79 Å2
Buried surface area: 16190.81 Å2
Dissociation area: 686.25 Å2
Dissociation energy (ΔGdiss): 0.94 kcal/mol
Dissociation entropy (TΔSdiss): 8.05 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-133824
Assembly 2
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Assembly Name: Complement C3d fragment and peptide
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Multimeric state: hetero tetramer
Accessible surface area: 50014.81 Å2
Buried surface area: 18968.22 Å2
Dissociation area: 710.2 Å2
Dissociation energy (ΔGdiss): -0.08 kcal/mol
Dissociation entropy (TΔSdiss): 8.04 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-133824

Macromolecules

Complement C3 beta chain
Chains: A, D
Length: 643 amino acids
Theoretical weight: 71.27 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: P01024 (Residues: 23-665; Coverage: 39%)
Gene names: C3, CPAMD1
Pfam:
InterPro:
CATH:
Complement C3 beta chain in PDB entry 2qki, assembly 1, front view.
Complement C3 beta chain in PDB entry 2qki, assembly 1, side view.
Complement C3 beta chain in PDB entry 2qki, assembly 1, top view.
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Complement C3c alpha' chain fragment 1
Chains: B, E
Length: 188 amino acids
Theoretical weight: 21.52 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: P01024 (Residues: 749-936; Coverage: 12%)
Gene names: C3, CPAMD1
Pfam: Alpha-2-macroglobulin family
InterPro:
CATH:
Complement C3c alpha' chain fragment 1 in PDB entry 2qki, assembly 1, front view.
Complement C3c alpha' chain fragment 1 in PDB entry 2qki, assembly 1, side view.
Complement C3c alpha' chain fragment 1 in PDB entry 2qki, assembly 1, top view.
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Complement C3c alpha' chain fragment 2
Chains: C, F
Length: 343 amino acids
Theoretical weight: 39.54 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: P01024 (Residues: 1321-1663; Coverage: 21%)
Gene names: C3, CPAMD1
Pfam:
InterPro:
CATH:
Complement C3c alpha' chain fragment 2 in PDB entry 2qki, assembly 1, front view.
Complement C3c alpha' chain fragment 2 in PDB entry 2qki, assembly 1, side view.
Complement C3c alpha' chain fragment 2 in PDB entry 2qki, assembly 1, top view.
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compstatin
Chains: G, H
Length: 15 amino acids
Theoretical weight: 1.6 KDa
compstatin in PDB entry 2qki, assembly 1, front view.
compstatin in PDB entry 2qki, assembly 1, side view.
compstatin in PDB entry 2qki, assembly 1, top view.
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