› 2qkc

X-ray diffraction
2.3Å resolution

Structural and Kinetic Study of the Differences between Human and E.coli Manganese Superoxide Dismutases

Released:
DOI: 10.2210/pdb2qkc/pdb
PDB entry 2qkc coloured by chain, front view.
PDB entry 2qkc coloured by chain, side view.
PDB entry 2qkc coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structural and kinetic study of differences between human and Escherichia coli manganese superoxide dismutases.
Zheng J, Domsic JF, Cabelli D, McKenna R, Silverman DN
Biochemistry 46 14830-7 (2007)
PMID: 18044968

Function and Biology Details

Reaction catalysed: 
2 superoxide + 2 H(+) = O(2) + H(2)O(2)
Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:
Structure domains:

Structure analysis Details

Assembly composition:
homo tetramer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-137485 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Superoxide dismutase [Mn], mitochondrial Chains: A, C
Molecule details ›
Chains: A, C
Length: 196 amino acids
Theoretical weight: 21.94 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P04179 (Residues: 25-220; Coverage: 88%)
Gene name: SOD2
Sequence domains:
Structure domains:

Ligands and Environments

1 bound ligand:
Ligand MN 2 x MN
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU RUH3R
Spacegroup: P6122
Unit cell:
a: 81.108Å b: 81.108Å c: 242.545Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.199 0.199 0.206
Expression system: Escherichia coli

Quick links

Citations

2 review citations

Superoxide dismutases and superoxide reductases.
Sheng et al. (2014)
1 more

4 mentions without citation

The structure-function relationships and physiological roles of MnSOD mutants.
Bonetta Valentino R. (2022)
3 more