› 2qjz

X-ray diffraction
1.25Å resolution

Structural Basis of Microtubule Plus End Tracking by XMAP215, CLIP-170 and EB1

Released:
DOI: 10.2210/pdb2qjz/pdb
PDB entry 2qjz coloured by chain, front view.
PDB entry 2qjz coloured by chain, side view.
PDB entry 2qjz coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structural basis of microtubule plus end tracking by XMAP215, CLIP-170, and EB1.
Slep KC, Vale RD
Mol Cell 27 976-91 (2007)
PMID: 17889670

Function and Biology Details

Biochemical function:
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-172375 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Microtubule-associated protein RP/EB family member 1 Chains: A, B
Molecule details ›
Chains: A, B
Length: 123 amino acids
Theoretical weight: 14.46 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q15691 (Residues: 12-133; Coverage: 46%)
Gene name: MAPRE1
Sequence domains: Calponin homology (CH) domain
Structure domains: Calponin-like domain

Ligands and Environments

No bound ligands
1 modified residue:
Ligand MSE 8 x MSE

Experiments and Validation Details

Entry percentile scores
X-ray source: ALS BEAMLINE 8.3.1
Spacegroup: P21
Unit cell:
a: 29.334Å b: 65.22Å c: 63.091Å
α: 90° β: 96.24° γ: 90°
R-values:
R R work R free
0.177 0.174 0.198
Expression system: Escherichia coli

Quick links

Citations

35 review citations

Tracking the ends: a dynamic protein network controls the fate of microtubule tips.
Akhmanova et al. (2008)
34 more

2 mentions without citation

Structural basis of microtubule plus end tracking by XMAP215, CLIP-170, and EB1.
Slep et al. (2007)
1 more