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Crystal structure of human FLAP with MK-591

X-ray diffraction
4.25Å resolution
PDB entry 2q7m coloured by chain, front view.
PDB entry 2q7m coloured by chain, side view.
PDB entry 2q7m coloured by chain, top view.
Source organism: Homo sapiens
Assembly composition:
homo trimer (preferred)
Entry contents: 1 distinct polypeptide molecule

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Arachidonate 5-lipoxygenase-activating protein
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Multimeric state: homo trimer
Accessible surface area: 19744.5 Å2
Buried surface area: 10893.7 Å2
Dissociation area: 4,669.27 Å2
Dissociation energy (ΔGdiss): 52.59 kcal/mol
Dissociation entropy (TΔSdiss): 26.23 kcal/mol
Symmetry number: 3
PDBe Complex ID: PDB-CPX-148927
Assembly 2
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Assembly Name: Arachidonate 5-lipoxygenase-activating protein
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Multimeric state: homo trimer
Accessible surface area: 19850.58 Å2
Buried surface area: 10818.88 Å2
Dissociation area: 4,623.5 Å2
Dissociation energy (ΔGdiss): 57.33 kcal/mol
Dissociation entropy (TΔSdiss): 26.21 kcal/mol
Symmetry number: 3
PDBe Complex ID: PDB-CPX-148927

Macromolecules

Arachidonate 5-lipoxygenase-activating protein
Chains: A, B, C, D, E, F
Length: 161 amino acids
Theoretical weight: 18.11 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P20292 (Residues: 1-161; Coverage: 100%)
Gene names: ALOX5AP, FLAP
Pfam: MAPEG family
InterPro:
SCOP: MAPEG domain
Arachidonate 5-lipoxygenase-activating protein in PDB entry 2q7m, assembly 1, front view.
Arachidonate 5-lipoxygenase-activating protein in PDB entry 2q7m, assembly 1, side view.
Arachidonate 5-lipoxygenase-activating protein in PDB entry 2q7m, assembly 1, top view.
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