X-ray diffraction
4.25Å resolution

Crystal structure of human FLAP with MK-591


Function and Biology Details

Structure analysis Details

Assembly composition:
homo trimer (preferred)
Entry contents:
1 distinct polypeptide molecule
Arachidonate 5-lipoxygenase-activating protein Chains: A, B, C, D, E, F
Molecule details ›
Chains: A, B, C, D, E, F
Length: 161 amino acids
Theoretical weight: 18.11 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
  • Canonical: P20292 (Residues: 1-161; Coverage: 100%)
Gene names: ALOX5AP, FLAP
Sequence domains: MAPEG family

Ligands and Environments

1 bound ligand:
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 17-ID
Spacegroup: P4212
Unit cell:
a: 180.6Å b: 180.6Å c: 140.57Å
α: 90° β: 90° γ: 90°
R R work R free
0.244 0.242 0.284
Expression system: Escherichia coli BL21(DE3)