› 2q7c

X-ray diffraction
2Å resolution

Crystal structure of IQN17

Released:
DOI: 10.2210/pdb2q7c/pdb
PDB entry 2q7c coloured by chain, front view.
PDB entry 2q7c coloured by chain, side view.
PDB entry 2q7c coloured by chain, top view.
Source organism: Human immunodeficiency virus 1
Primary publication:
Inhibiting HIV-1 entry: discovery of D-peptide inhibitors that target the gp41 coiled-coil pocket.
Eckert DM, Malashkevich VN, Hong LH, Carr PA, Kim PS
Cell 99 103-15 (1999)
PMID: 10520998

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Structure domain:

Structure analysis Details

Assembly composition:
homo trimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-107124 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Transmembrane protein gp41 Chains: A, B, C
Molecule details ›
Chains: A, B, C
Length: 46 amino acids
Theoretical weight: 5.47 KDa
Source organism: Human immunodeficiency virus 1
Expression system: Not provided
UniProt:
  • Canonical: A3F986 (Residues: 542-583; Coverage: 5%)
Gene name: env
Structure domains: Single alpha-helices involved in coiled-coils or other helix-helix interfaces

Ligands and Environments

1 bound ligand:
Ligand CL 4 x CL
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: NSLS BEAMLINE X4A
Spacegroup: P212121
Unit cell:
a: 24.986Å b: 39.846Å c: 135.396Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.238 0.234 0.31
Expression system: Not provided

Quick links

Citations

64 review citations

Mechanisms of viral membrane fusion and its inhibition.
Eckert et al. (2001)
63 more

2 mentions without citation

Computer-Aided Approaches for Targeting HIVgp41.
Allen et al. (2012)
1 more