› 2q61

X-ray diffraction
2.2Å resolution

Crystal Structure of PPARgamma ligand binding domain bound to partial agonist SR145

Released:
DOI: 10.2210/pdb2q61/pdb
PDB 2q61 coloured by chain and viewed from the front.
PDB 2q61 coloured by chain and viewed from the side.
PDB 2q61 coloured by chain and viewed from the top.
Source organism: Homo sapiens
Primary publication:
Partial agonists activate PPARgamma using a helix 12 independent mechanism.
Bruning JB, Chalmers MJ, Prasad S, Busby SA, Kamenecka TM, He Y, Nettles KW, Griffin PR
Structure 15 1258-71 (2007)
PMID: 17937915

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Peroxisome proliferator-activated receptor gamma Chains: A, B
Molecule details ›
Chains: A, B
Length: 274 amino acids
Theoretical weight: 31.3 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P37231 (Residues: 233-505; Coverage: 54%)
Gene names: NR1C3, PPARG
Sequence domains: Ligand-binding domain of nuclear hormone receptor
Structure domains: Retinoid X Receptor

Ligands and Environments

1 bound ligand:
Ligand SF1 2 x SF1
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SSRL BEAMLINE BL11-1
Spacegroup: C2
Unit cell:
a: 90.131Å b: 62.39Å c: 117.93Å
α: 90° β: 100.98° γ: 90°
R-values:
R R work R free
0.19 0.188 0.229
Expression system: Escherichia coli

Quick links

Citations

21 review citations

Structural Biology-Based Exploration of Subtype-Selective Agonists for Peroxisome Proliferator-Activated Receptors.
Miyachi H. (2021)
20 more

5 mentions without citation

Review of the Structural and Dynamic Mechanisms of PPARĪ³ Partial Agonism.
Kroker et al. (2015)
4 more