2q3e

X-ray diffraction
2Å resolution

Structure of human UDP-glucose dehydrogenase complexed with NADH and UDP-glucose

Released:
Source organism: Homo sapiens
Primary publication:
Structure and mechanism of human UDP-glucose 6-dehydrogenase.
OpenAccess logo J. Biol. Chem. 286 23877-87 (2011)
PMID: 21502315

Function and Biology Details

Structure analysis Details

Assembly composition:
homo hexamer (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
UDP-glucose 6-dehydrogenase Chains: A, B, C, D, E, F, G, H, I, J, K, L
Molecule details ›
Chains: A, B, C, D, E, F, G, H, I, J, K, L
Length: 467 amino acids
Theoretical weight: 52.08 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: O60701 (Residues: 1-466; Coverage: 94%)
Gene name: UGDH
Sequence domains:
Structure domains:

Ligands and Environments


Cofactor: Ligand NAI 12 x NAI
2 bound ligands:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SLS BEAMLINE X10SA
Spacegroup: P21
Unit cell:
a: 115.99Å b: 184.132Å c: 170.943Å
α: 90° β: 109.23° γ: 90°
R-values:
R R work R free
0.173 0.172 0.205
Expression system: Escherichia coli BL21(DE3)