› 2q0a

X-ray diffraction
2.25Å resolution

Structure and rearrangements in the carboxy-terminal region of SpIH channels

Released:
DOI: 10.2210/pdb2q0a/pdb
PDB 2q0a coloured by chain and viewed from the front.
PDB 2q0a coloured by chain and viewed from the side.
PDB 2q0a coloured by chain and viewed from the top.
Source organism: Mus musculus
Primary publication:
Structure and rearrangements in the carboxy-terminal region of SpIH channels.
Flynn GE, Black KD, Islas LD, Sankaran B, Zagotta WN
Structure 15 671-82 (2007)
PMID: 17562314

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:
Structure domain:

Structure analysis Details

Assemblies composition:
homo tetramer
monomeric
homo octamer (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2 Chains: A, B
Molecule details ›
Chains: A, B
Length: 200 amino acids
Theoretical weight: 23.43 KDa
Source organism: Mus musculus
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: O88703 (Residues: 443-640; Coverage: 23%)
Gene names: Bcng2, Hac1, Hcn2
Sequence domains: Cyclic nucleotide-binding domain
Structure domains:

Ligands and Environments

1 bound ligand:
Ligand PCG 2 x PCG
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ALS BEAMLINE 8.2.1
Spacegroup: I4
Unit cell:
a: 94.734Å b: 94.734Å c: 124.047Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.209 0.209 0.261
Expression system: Escherichia coli BL21(DE3)

Quick links

Citations

7 review citations

Retinal Cyclic Nucleotide-Gated Channels: From Pathophysiology to Therapy.
Michalakis et al. (2018)
6 more

1 mention without citation

The glutamic acid-rich protein is a gating inhibitor of cyclic nucleotide-gated channels.
Michalakis et al. (2011)