› 2q0a

X-ray diffraction
2.25Å resolution

Structure and rearrangements in the carboxy-terminal region of SpIH channels

Released:
DOI: 10.2210/pdb2q0a/pdb
PDB entry 2q0a coloured by chain, front view.
PDB entry 2q0a coloured by chain, side view.
PDB entry 2q0a coloured by chain, top view.
Source organism: Mus musculus
Primary publication:
Structure and rearrangements in the carboxy-terminal region of SpIH channels.
Flynn GE, Black KD, Islas LD, Sankaran B, Zagotta WN
Structure 15 671-82 (2007)
PMID: 17562314

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:
Structure domain:

Structure analysis Details

Assemblies composition:
homo tetramer
monomeric (preferred)
homo octamer
Assembly name:
PDBe Complex ID:
PDB-CPX-131574 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2 Chains: A, B
Molecule details ›
Chains: A, B
Length: 200 amino acids
Theoretical weight: 23.43 KDa
Source organism: Mus musculus
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: O88703 (Residues: 443-640; Coverage: 23%)
Gene names: Bcng2, Hac1, Hcn2
Sequence domains: Cyclic nucleotide-binding domain
Structure domains:

Ligands and Environments

1 bound ligand:
Ligand PCG 2 x PCG
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ALS BEAMLINE 8.2.1
Spacegroup: I4
Unit cell:
a: 94.734Å b: 94.734Å c: 124.047Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.209 0.209 0.261
Expression system: Escherichia coli BL21(DE3)

Quick links

Citations

8 review citations

Hyperpolarization-activated cation channels: from genes to function.
Biel et al. (2009)
7 more

2 mentions without citation

The glutamic acid-rich protein is a gating inhibitor of cyclic nucleotide-gated channels.
Michalakis et al. (2011)
1 more