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Crystal structure of Staphylococcal nuclease variant V66Q/P117G/H124L/S128A at 100 K

Source organism: Staphylococcus aureus
Biochemical function: nuclease activity
Biological process: not assigned
Cellular component: not assigned

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EC 3.1.31.1: Micrococcal nuclease

Reaction catalysed:
Endonucleolytic cleavage to nucleoside 3'-phosphates and 3'-phosphooligonucleotide end-products
Systematic name:
-
Alternative Name(s):
  • Micrococcal endonuclease
  • Nuclease T
  • Nuclease T'
  • Ribonucleate (deoxynucleate) 3'-nucleotidohydrolase
  • Spleen endonuclease
  • Spleen phosphodiesterase
  • Staphylococcal nuclease
  • Staphylococcus aureus nuclease
  • Staphylococcus aureus nuclease B
  • Thermonuclease

GO terms

Biochemical function:
Biological process:
  • not assigned
Cellular component:
  • not assigned

Sequence family

Pfam Protein family (Pfam)
PF00565
Domain description: Staphylococcal nuclease homologue
Occurring in:
  1. Thermonuclease
The deposited structure of PDB entry 2pzt contains 1 copy of Pfam domain PF00565 (Staphylococcal nuclease homologue) in Thermonuclease. Showing 1 copy in chain A.

InterPro InterPro annotations
IPR002071
Domain description: Thermonuclease active site
Occurring in:
  1. Thermonuclease
IPR016071
Domain description: Staphylococcal nuclease (SNase-like), OB-fold
Occurring in:
  1. Thermonuclease
IPR035437
Domain description: SNase-like, OB-fold superfamily
Occurring in:
  1. Thermonuclease

Structure domain

CATH CATH domain
2.40.50.90
Class: Mainly Beta
Architecture: Beta Barrel
Topology: OB fold (Dihydrolipoamide Acetyltransferase, E2P)
Homology: OB fold (Dihydrolipoamide Acetyltransferase, E2P)
Occurring in:
  1. Thermonuclease
The deposited structure of PDB entry 2pzt contains 1 copy of CATH domain 2.40.50.90 (OB fold (Dihydrolipoamide Acetyltransferase, E2P)) in Thermonuclease. Showing 1 copy in chain A.

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