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Crystal Structure of FGF Receptor 2 (FGFR2) Kinase Domain Harboring the Pathogenic K659N Mutation Responsible for an Unclassified Craniosynostosis Syndrome.

X-ray diffraction
2.2Å resolution
PDB entry 2pvy coloured by chain, front view.
PDB entry 2pvy coloured by chain, side view.
PDB entry 2pvy coloured by chain, top view.
Source organism: Homo sapiens
Assembly composition:
homo tetramer (preferred)
Entry contents: 1 distinct polypeptide molecule

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Fibroblast growth factor receptor 2
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Multimeric state: homo tetramer
Accessible surface area: 48743.64 Å2
Buried surface area: 11450.86 Å2
Dissociation area: 1,566.77 Å2
Dissociation energy (ΔGdiss): 10.17 kcal/mol
Dissociation entropy (TΔSdiss): 14.5 kcal/mol
Symmetry number: 2
PDBe Complex ID: PDB-CPX-149431

Macromolecules

Fibroblast growth factor receptor 2
Chains: A, B, C, D
Length: 324 amino acids
Theoretical weight: 37.1 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P21802 (Residues: 458-768; Coverage: 39%)
Gene names: BEK, FGFR2, KGFR, KSAM
Pfam: Protein tyrosine and serine/threonine kinase
InterPro:
CATH:
Fibroblast growth factor receptor 2 in PDB entry 2pvy, assembly 1, front view.
Fibroblast growth factor receptor 2 in PDB entry 2pvy, assembly 1, side view.
Fibroblast growth factor receptor 2 in PDB entry 2pvy, assembly 1, top view.
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