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The structure of Plasmodium falciparum spermidine synthase in complex with decarboxylated S-adenosylmethionine and the inhibitor cis-4-methylcyclohexylamine (4MCHA)

X-ray diffraction
2.2Å resolution
PDB entry 2pt9 coloured by chain, front view.
PDB entry 2pt9 coloured by chain, side view.
PDB entry 2pt9 coloured by chain, top view.
Source organism: Plasmodium falciparum 3D7
Assembly composition:
homo dimer (preferred)
Entry contents: 1 distinct polypeptide molecule

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Assemblies

Assembly 1
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Assembly Name: PABS domain-containing protein
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Multimeric state: homo dimer
Accessible surface area: 21222.81 Å2
Buried surface area: 7202.32 Å2
Dissociation area: 2,057.15 Å2
Dissociation energy (ΔGdiss): 0.03 kcal/mol
Dissociation entropy (TΔSdiss): 13.63 kcal/mol
Symmetry number: 2
PDBe Complex ID: PDB-CPX-184780
Assembly 2 (preferred)
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Assembly Name: PABS domain-containing protein
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Multimeric state: homo dimer
Accessible surface area: 21378.61 Å2
Buried surface area: 6576.66 Å2
Dissociation area: 1,757.1 Å2
Dissociation energy (ΔGdiss): 13.22 kcal/mol
Dissociation entropy (TΔSdiss): 13.54 kcal/mol
Symmetry number: 2
PDBe Complex ID: PDB-CPX-184780

Macromolecules

PABS domain-containing protein
Chains: A, B, C
Length: 321 amino acids
Theoretical weight: 36.64 KDa
Source organism: Plasmodium falciparum 3D7
Expression system: Escherichia coli
UniProt:
  • Canonical: Q8II73 (Residues: 1-321; Coverage: 100%)
Gene name: PF3D7_1129000
Pfam:
InterPro:
CATH:
PABS domain-containing protein in PDB entry 2pt9, assembly 2, front view.
PABS domain-containing protein in PDB entry 2pt9, assembly 2, side view.
PABS domain-containing protein in PDB entry 2pt9, assembly 2, top view.
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