› 2psr

X-ray diffraction
2.05Å resolution

HUMAN PSORIASIN (S100A7) CA2+ AND ZN2+ BOUND FORM (CRYSTAL FORM II)

Released:
DOI: 10.2210/pdb2psr/pdb
PDB entry 2psr coloured by chain, front view.
PDB entry 2psr coloured by chain, side view.
PDB entry 2psr coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Zinc-binding site of an S100 protein revealed. Two crystal structures of Ca2+-bound human psoriasin (S100A7) in the Zn2+-loaded and Zn2+-free states.
Brodersen DE, Nyborg J, Kjeldgaard M
Biochemistry 38 1695-704 (1999)
PMID: 10026247

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-151915 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Protein S100-A7 Chain: A
Molecule details ›
Chain: A
Length: 100 amino acids
Theoretical weight: 11.34 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21
UniProt:
  • Canonical: P31151 (Residues: 2-101; Coverage: 99%)
Gene names: PSOR1, S100A7, S100A7C
Sequence domains: S-100/ICaBP type calcium binding domain
Structure domains: EF-hand

Ligands and Environments

2 bound ligands:
Ligand CA 1 x CA
Ligand ZN 1 x ZN
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: EMBL/DESY, HAMBURG BEAMLINE BW7B
Spacegroup: P43212
Unit cell:
a: 51.958Å b: 51.958Å c: 116.027Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.216 not available 0.264
Expression system: Escherichia coli BL21

Quick links

Citations

21 review citations

Calcium-dependent and -independent interactions of the S100 protein family.
Santamaria-Kisiel et al. (2006)
20 more

13 mentions without citation

Manganese and microbial pathogenesis: sequestration by the Mammalian immune system and utilization by microorganisms.
Brophy et al. (2015)
12 more