2prz

X-ray diffraction
1.9Å resolution

S. cerevisiae orotate phosphoribosyltransferase complexed with OMP

Released:

Function and Biology Details

Reaction catalysed:
Orotidine 5'-phosphate + diphosphate = orotate + 5-phospho-alpha-D-ribose 1-diphosphate
Biochemical function:
Cellular component:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
PDBe Complex ID:
PDB-CPX-146536 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Orotate phosphoribosyltransferase 1 Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 226 amino acids
Theoretical weight: 24.69 KDa
Source organism: Saccharomyces cerevisiae
Expression system: Escherichia coli
UniProt:
  • Canonical: P13298 (Residues: 1-226; Coverage: 100%)
Gene names: PYR5, URA5, YM8339.13, YML106W
Sequence domains: Phosphoribosyl transferase domain
Structure domains: Rossmann fold

Ligands and Environments

2 bound ligands:
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 19-ID
Spacegroup: P212121
Unit cell:
a: 86.063Å b: 99.475Å c: 111.995Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.23 0.229 0.262
Expression system: Escherichia coli