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Structure of the Wilms Tumor Suppressor Protein Zinc Finger Domain Bound to DNA

X-ray diffraction
3.15Å resolution
PDB entry 2prt coloured by chain, front view.
PDB entry 2prt coloured by chain, side view.
PDB entry 2prt coloured by chain, top view.
Source organism: Homo sapiens
Assembly composition:
hetero trimer (preferred)
Entry contents: 1 distinct polypeptide molecule
2 distinct DNA molecules

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Wilms tumor protein and DNA
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Multimeric state: hetero trimer
Accessible surface area: 11334.84 Å2
Buried surface area: 4161.06 Å2
Dissociation area: 1,492.16 Å2
Dissociation energy (ΔGdiss): 10.86 kcal/mol
Dissociation entropy (TΔSdiss): 11.38 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-115777

Macromolecules

Wilms tumor protein
Chain: A
Length: 119 amino acids
Theoretical weight: 14.49 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P19544 (Residues: 318-438; Coverage: 26%)
Gene name: WT1
Pfam: Zinc finger, C2H2 type
InterPro:
CATH: Classic Zinc Finger
Wilms tumor protein in PDB entry 2prt, assembly 1, front view.
Wilms tumor protein in PDB entry 2prt, assembly 1, side view.
Wilms tumor protein in PDB entry 2prt, assembly 1, top view.
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DNA chain B
Name: DNA (5'-D(*CP*GP*CP*GP*GP*GP*GP*GP*CP*GP*TP*CP*TP*G)-3')
Representative chains: B
Source organism: Homo sapiens [9606]
Expression system: Not provided
Length: 14 nucleotides
Theoretical weight: 4.35 KDa
DNA (5'-D(*CP*GP*CP*GP*GP*GP*GP*GP*CP*GP*TP*CP*TP*G)-3') in PDB entry 2prt, assembly 1, front view.
DNA (5'-D(*CP*GP*CP*GP*GP*GP*GP*GP*CP*GP*TP*CP*TP*G)-3') in PDB entry 2prt, assembly 1, side view.
DNA (5'-D(*CP*GP*CP*GP*GP*GP*GP*GP*CP*GP*TP*CP*TP*G)-3') in PDB entry 2prt, assembly 1, top view.
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DNA chain C
Name: DNA (5'-D(*CP*AP*GP*AP*CP*GP*CP*CP*CP*CP*CP*GP*CP*G)-3')
Representative chains: C
Source organism: Homo sapiens [9606]
Expression system: Not provided
Length: 14 nucleotides
Theoretical weight: 4.21 KDa
DNA (5'-D(*CP*AP*GP*AP*CP*GP*CP*CP*CP*CP*CP*GP*CP*G)-3') in PDB entry 2prt, assembly 1, front view.
DNA (5'-D(*CP*AP*GP*AP*CP*GP*CP*CP*CP*CP*CP*GP*CP*G)-3') in PDB entry 2prt, assembly 1, side view.
DNA (5'-D(*CP*AP*GP*AP*CP*GP*CP*CP*CP*CP*CP*GP*CP*G)-3') in PDB entry 2prt, assembly 1, top view.
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