Structure analysis

PPARgamma Ligand binding domain complexed with a farglitazar analogue gw4709

X-ray diffraction
2.3Å resolution
Source organism: Homo sapiens
Assembly composition:
homo dimer (preferred)
Entry contents: 1 distinct polypeptide molecule

Assemblies

Assembly 1 (preferred)
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Multimeric state: homo dimer
Accessible surface area: 24100 Å2
Buried surface area: 3400 Å2
Dissociation area: 900 Å2
Dissociation energy (ΔGdiss): 1 kcal/mol
Dissociation entropy (TΔSdiss): 13 kcal/mol
Interface energy (ΔGint): -17 kcal/mol
Symmetry number: 1

Macromolecules

Chains: A, B
Length: 272 amino acids
Theoretical weight: 31.09 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P37231 (Residues: 234-505; Coverage: null%)
Gene names: NR1C3, PPARG
InterPro:
CATH: Retinoid X Receptor
SCOP: Nuclear receptor ligand-binding domain

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