X-ray diffraction
2.91Å resolution

Crystal structure of the complex of human lactoferrin N-lobe and lactoferrin-binding domain of pneumococcal surface protein A


Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Lactotransferrin Chains: A, B
Molecule details ›
Chains: A, B
Length: 344 amino acids
Theoretical weight: 38.28 KDa
Source organism: Homo sapiens
Expression system: Insect cells
  • Canonical: P02788 (Residues: 21-362; Coverage: 50%)
Gene names: GIG12, LF, LTF
Sequence domains: Transferrin
Structure domains: Periplasmic binding protein-like II
Pneumococcal surface protein A Chains: C, D
Molecule details ›
Chains: C, D
Length: 125 amino acids
Theoretical weight: 14.12 KDa
Source organism: Streptococcus pneumoniae
Expression system: Escherichia coli BL21(DE3)
  • Canonical: Q54972 (Residues: 199-319; Coverage: 21%)
Gene name: pspA
Structure domains: Helix Hairpins

Ligands and Environments

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 17-ID
Spacegroup: P32
Unit cell:
a: 130.18Å b: 130.18Å c: 80.8Å
α: 90° β: 90° γ: 120°
R R work R free
0.205 0.203 0.249
Expression systems:
  • Insect cells
  • Escherichia coli BL21(DE3)