X-ray diffraction
1.5Å resolution

Crystal structure of M tuberculosis Adenosine Kinase (apo)

Source organism: Mycobacterium tuberculosis
Entry authors: Reddy MCM, Palaninathan SK, Shetty ND, Owen JL, Watson MD, Sacchettini JC, TB Structural Genomics Consortium (TBSGC)

Function and Biology Details

Reaction catalysed:
ATP + adenosine = ADP + AMP
Biochemical function:
Biological process:
Cellular component:

Structure analysis Details

Assemblies composition:
homo dimer
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
Adenosine kinase Chains: A, B
Molecule details ›
Chains: A, B
Length: 334 amino acids
Theoretical weight: 35.68 KDa
Source organism: Mycobacterium tuberculosis
Expression system: Escherichia coli
  • Canonical: P9WID5 (Residues: 1-324; Coverage: 100%)
Gene names: MTCY190.13c, Rv2202c, adoK, cbhK
Sequence domains: pfkB family carbohydrate kinase
Structure domains: UDP-N-acetylmuramoyl-L-alanine:D-glutamate ligase

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 23-ID-B
Spacegroup: C2
Unit cell:
a: 114.272Å b: 75.184Å c: 94.73Å
α: 90° β: 121.05° γ: 90°
R R work R free
0.176 0.175 0.198
Expression system: Escherichia coli