› 2pjl

X-ray diffraction
2.3Å resolution

Crystal Structure of Human Estrogen-Related Receptor alpha in Complex with a Synthetic Inverse Agonist reveals its Novel Molecular Mechanism

Released:
DOI: 10.2210/pdb2pjl/pdb
PDB 2pjl coloured by chain and viewed from the front.
PDB 2pjl coloured by chain and viewed from the side.
PDB 2pjl coloured by chain and viewed from the top.
Source organism: Homo sapiens
Primary publication:
Crystal structure of human estrogen-related receptor alpha in complex with a synthetic inverse agonist reveals its novel molecular mechanism.
Kallen J, Lattmann R, Beerli R, Blechschmidt A, Blommers MJ, Geiser M, Ottl J, Schlaeppi JM, Strauss A, Fournier B
J. Biol. Chem. 282 23231-9 (2007)
PMID: 17556356

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
homo hexamer (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Steroid hormone receptor ERR1 Chains: A, B
Molecule details ›
Chains: A, B
Length: 247 amino acids
Theoretical weight: 27.02 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: P11474 (Residues: 193-423; Coverage: 55%)
Gene names: ERR1, ESRL1, ESRRA, NR3B1
Sequence domains: Ligand-binding domain of nuclear hormone receptor
Structure domains: Retinoid X Receptor

Ligands and Environments

1 bound ligand:
Ligand 047 2 x 047
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SLS BEAMLINE X10SA
Spacegroup: R3
Unit cell:
a: 96.465Å b: 96.465Å c: 134.59Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.222 0.219 0.281
Expression system: Spodoptera frugiperda

Quick links

Citations

13 review citations

Molecular dynamics of estrogen-related receptors and their regulatory proteins: roles in transcriptional control for endocrine and metabolic signaling.
Tanida T. (2021)
12 more

7 mentions without citation

A novel steroidal inhibitor of estrogen-related receptor alpha (ERR alpha).
Duellman et al. (2010)
6 more