X-ray diffraction
2.3Å resolution

Crystal Structure of Human Estrogen-Related Receptor alpha in Complex with a Synthetic Inverse Agonist reveals its Novel Molecular Mechanism


Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
homo hexamer (preferred)
Entry contents:
1 distinct polypeptide molecule
Steroid hormone receptor ERR1 Chains: A, B
Molecule details ›
Chains: A, B
Length: 247 amino acids
Theoretical weight: 27.02 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
  • Canonical: P11474 (Residues: 193-423; Coverage: 55%)
Gene names: ERR1, ESRL1, ESRRA, NR3B1
Sequence domains: Ligand-binding domain of nuclear hormone receptor
Structure domains: Retinoid X Receptor

Ligands and Environments

1 bound ligand:
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SLS BEAMLINE X10SA
Spacegroup: R3
Unit cell:
a: 96.465Å b: 96.465Å c: 134.59Å
α: 90° β: 90° γ: 120°
R R work R free
0.222 0.219 0.281
Expression system: Spodoptera frugiperda