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Crystal structure of E. coli MltA with bound chitohexaose

Source organism: Escherichia coli K-12
Biochemical function: lyase activity
Biological process: cell wall organization
Cellular component: outer membrane-bounded periplasmic space

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EC 4.2.2.n1: Peptidoglycan lytic exotransglycosylase

Reaction catalysed:
Exolytic cleavage of the (1->4)-beta-glycosidic linkage between N-acetylmuramic acid (MurNAc) and N-acetylglucosamine (GlcNAc) residues in peptidoglycan, from either the reducing or the non-reducing ends of the peptidoglycan chains, with concomitant formation of a 1,6-anhydrobond in the MurNAc residue.
Systematic name:
Peptidoglycan lytic exotransglycosylase
Alternative Name(s):
  • Exomuramidase
  • MltF
  • Murein lyase F

GO terms

Sequence families

Pfam Protein families (Pfam)
PF06725
Domain description: 3D domain
Occurring in:
  1. Membrane-bound lytic murein transglycosylase A
The deposited structure of PDB entry 2pi8 contains 4 copies of Pfam domain PF06725 (3D domain) in Membrane-bound lytic murein transglycosylase A. Showing 1 copy in chain B.

PF03562
Domain description: MltA specific insert domain
Occurring in:
  1. Membrane-bound lytic murein transglycosylase A
The deposited structure of PDB entry 2pi8 contains 4 copies of Pfam domain PF03562 (MltA specific insert domain) in Membrane-bound lytic murein transglycosylase A. Showing 1 copy in chain B.

InterPro InterPro annotations
IPR026044
Domain description: Membrane-bound lytic murein transglycosylase A
Occurring in:
  1. Membrane-bound lytic murein transglycosylase A
IPR005300
Domain description: Lytic transglycosylase MltA, domain B
Occurring in:
  1. Membrane-bound lytic murein transglycosylase A
IPR036908
Domain description: RlpA-like domain superfamily
Occurring in:
  1. Membrane-bound lytic murein transglycosylase A
IPR010611
Domain description: 3D domain
Occurring in:
  1. Membrane-bound lytic murein transglycosylase A

Structure domains

CATH CATH domains
2.40.40.10
Class: Mainly Beta
Architecture: Beta Barrel
Topology: Barwin-like endoglucanases
Homology: RlpA-like domain
Occurring in:
  1. Membrane-bound lytic murein transglycosylase A
The deposited structure of PDB entry 2pi8 contains 4 copies of CATH domain 2.40.40.10 (Barwin-like endoglucanases) in Membrane-bound lytic murein transglycosylase A. Showing 1 copy in chain B.
2.40.240.50
Class: Mainly Beta
Architecture: Beta Barrel
Topology: Ribosomal Protein L25; Chain P
Homology: Barwin-like endoglucanases
Occurring in:
  1. Membrane-bound lytic murein transglycosylase A
The deposited structure of PDB entry 2pi8 contains 4 copies of CATH domain 2.40.240.50 (Ribosomal Protein L25; Chain P) in Membrane-bound lytic murein transglycosylase A. Showing 1 copy in chain B.
SCOP SCOP annotation
159195
Class: All beta proteins
Fold: Double psi beta-barrel
Superfamily: Barwin-like endoglucanases
Occurring in:
  1. Membrane-bound lytic murein transglycosylase A
The deposited structure of PDB entry 2pi8 contains 4 copies of SCOP domain 159195 (MLTA-like) in Membrane-bound lytic murein transglycosylase A. Showing 1 copy in chain B.

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