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CRYSTAL STRUCTURE OF HUMAN PHOSPHOINOSITIDE-DEPENDENT PROTEIN KINASE 1 (PDK1) 5-Hydroxy-3-[1-(1H-pyrrol-2-yl)-eth-(Z)-ylidene]-1,3-dihydro-indol-2-one COMPLEX

X-ray diffraction
2.35Å resolution
PDB entry 2pe0 coloured by chain, front view.
PDB entry 2pe0 coloured by chain, side view.
PDB entry 2pe0 coloured by chain, top view.
Source organism: Homo sapiens
Assembly composition:
monomeric (preferred)
Entry contents: 1 distinct polypeptide molecule

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Assemblies

Assembly 1 (preferred)
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Assembly Name: 3-phosphoinositide-dependent protein kinase 1
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Multimeric state: monomeric
PDBe Complex ID: PDB-CPX-127511

Macromolecules

3-phosphoinositide-dependent protein kinase 1
Chain: A
Length: 286 amino acids
Theoretical weight: 33.13 KDa
Source organism: Homo sapiens
Expression system: unidentified baculovirus
UniProt:
  • Canonical: O15530 (Residues: 74-359; Coverage: 51%)
Gene names: PDK1, PDPK1
Pfam: Protein kinase domain
InterPro:
CATH:
SCOP: Protein kinases, catalytic subunit
3-phosphoinositide-dependent protein kinase 1 in PDB entry 2pe0, assembly 1, front view.
3-phosphoinositide-dependent protein kinase 1 in PDB entry 2pe0, assembly 1, side view.
3-phosphoinositide-dependent protein kinase 1 in PDB entry 2pe0, assembly 1, top view.
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