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Human carboxypeptidase A4 in complex with a cleaved hexapeptide.

X-ray diffraction
1.6Å resolution
PDB entry 2pcu coloured by chain, front view.
PDB entry 2pcu coloured by chain, side view.
PDB entry 2pcu coloured by chain, top view.
Source organism: Homo sapiens
Assembly composition:
hetero dimer (preferred)
Entry contents: 2 distinct polypeptide molecules

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Carboxypeptidase A4 and peptide
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Multimeric state: hetero dimer
Accessible surface area: 12354.97 Å2
Buried surface area: 1684.01 Å2
Dissociation area: 512.83 Å2
Dissociation energy (ΔGdiss): 14.54 kcal/mol
Dissociation entropy (TΔSdiss): 6.49 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-163159

Macromolecules

Carboxypeptidase A4
Chain: A
Length: 305 amino acids
Theoretical weight: 34.23 KDa
Source organism: Homo sapiens
Expression system: Komagataella pastoris
UniProt:
  • Canonical: Q9UI42 (Residues: 116-420; Coverage: 75%)
Gene names: CPA3, CPA4, UNQ694/PRO1339
Pfam: Zinc carboxypeptidase
InterPro:
CATH: Zn peptidases
SCOP: Pancreatic carboxypeptidases
Carboxypeptidase A4 in PDB entry 2pcu, assembly 1, front view.
Carboxypeptidase A4 in PDB entry 2pcu, assembly 1, side view.
Carboxypeptidase A4 in PDB entry 2pcu, assembly 1, top view.
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peptide
Chain: B
Length: 5 amino acids
Theoretical weight: 633 Da
Source organism: Homo sapiens
Expression system: Not provided
peptide in PDB entry 2pcu, assembly 1, front view.
peptide in PDB entry 2pcu, assembly 1, side view.
peptide in PDB entry 2pcu, assembly 1, top view.
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