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Structural genomics of protein phosphatases.

Almo SC, Bonanno JB, Sauder JM, Emtage S, Dilorenzo TP, Malashkevich V, Wasserman SR, Swaminathan S, Eswaramoorthy S, Agarwal R, Kumaran D, Madegowda M, Ragumani S, Patskovsky Y, Alvarado J, Ramagopal UA, Faber-Barata J, Chance MR, Sali A, Fiser A, Zhang ZY, Lawrence DS, Burley SK
J Struct Funct Genomics 8 121-40 (2007)
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Cited: 87 times
EuropePMC logo PMID: 18058037

Abstract

The New York SGX Research Center for Structural Genomics (NYSGXRC) of the NIGMS Protein Structure Initiative (PSI) has applied its high-throughput X-ray crystallographic structure determination platform to systematic studies of all human protein phosphatases and protein phosphatases from biomedically-relevant pathogens. To date, the NYSGXRC has determined structures of 21 distinct protein phosphatases: 14 from human, 2 from mouse, 2 from the pathogen Toxoplasma gondii, 1 from Trypanosoma brucei, the parasite responsible for African sleeping sickness, and 2 from the principal mosquito vector of malaria in Africa, Anopheles gambiae. These structures provide insights into both normal and pathophysiologic processes, including transcriptional regulation, regulation of major signaling pathways, neural development, and type 1 diabetes. In conjunction with the contributions of other international structural genomics consortia, these efforts promise to provide an unprecedented database and materials repository for structure-guided experimental and computational discovery of inhibitors for all classes of protein phosphatases.

Reviews - 2pbn mentioned but not cited (1)

  1. Structural genomics of protein phosphatases. Almo SC, Bonanno JB, Sauder JM, Emtage S, Dilorenzo TP, Malashkevich V, Wasserman SR, Swaminathan S, Eswaramoorthy S, Agarwal R, Kumaran D, Madegowda M, Ragumani S, Patskovsky Y, Alvarado J, Ramagopal UA, Faber-Barata J, Chance MR, Sali A, Fiser A, Zhang ZY, Lawrence DS, Burley SK. J Struct Funct Genomics 8 121-140 (2007)


Reviews citing this publication (24)

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Articles citing this publication (62)

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  50. A novel binding pocket in the D2 domain of protein tyrosine phosphatase mu (PTPmu) guides AI screen to identify small molecules that modulate tumour cell adhesion, growth and migration. Molyneaux K, Laggner C, Brady-Kalnay SM. J Cell Mol Med 27 3553-3564 (2023)
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  52. Oxidative stress promotes fibrosis in systemic sclerosis through stabilization of a kinase-phosphatase complex. Zhang R, Kumar GS, Hansen U, Zoccheddu M, Sacchetti C, Holmes ZJ, Lee MC, Beckmann D, Wen Y, Mikulski Z, Yang S, Santelli E, Page R, Boin F, Peti W, Bottini N. JCI Insight 7 e155761 (2022)
  53. Structure-activity studies of PTPRD phosphatase inhibitors identify a 7-cyclopentymethoxy illudalic acid analog candidate for development. Henderson IM, Zeng F, Bhuiyan NH, Luo D, Martinez M, Smoake J, Bi F, Perera C, Johnson D, Prisinzano TE, Wang W, Uhl GR. Biochem Pharmacol 195 114868 (2022)
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  55. The biosynthetic origin of ribofuranose in bacterial polysaccharides. Kelly SD, Williams DM, Nothof JT, Kim T, Lowary TL, Kimber MS, Whitfield C. Nat Chem Biol 18 530-537 (2022)
  56. The inhibitory mechanism of aurintricarboxylic acid targeting serine/threonine phosphatase Stp1 in Staphylococcus aureus: insights from molecular dynamics simulations. Liu TT, Yang T, Gao MN, Chen KX, Yang S, Yu KQ, Jiang HL. Acta Pharmacol Sin 40 850-858 (2019)
  57. A unique mRNA decapping complex in trypanosomes. Kramer S, Karolak NK, Odenwald J, Gabiatti B, Castañeda Londoño PA, Zavřelová A, Freire ER, Almeida KS, Braune S, Moreira C, Eder A, Goos C, Field M, Carrington M, Holetz F, Górna MW, Zoltner M. Nucleic Acids Res 51 7520-7540 (2023)
  58. Clustering of phosphatase RPTPα promotes Src signaling and the arthritogenic action of synovial fibroblasts. Sendo S, Kiosses WB, Yang S, Wu DJ, Lee DWK, Liu L, Aschner Y, Vela AJ, Downey GP, Santelli E, Bottini N. Sci Signal 16 eabn8668 (2023)
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  60. Small molecule antagonists of PTPmu identified by artificial intelligence-based computational screening block glioma cell migration and growth. Molyneaux K, Laggner C, Vincent J, Brady-Kalnay S. PLoS One 18 e0288980 (2023)
  61. Structure-Activity Relationship of Synthetic Ginkgolic Acid Analogs for Treating Type 2 Diabetes by PTPN9 Inhibition. Kim J, Son J, Ahn D, Nam G, Zhao X, Park H, Jeong W, Chung SJ. Int J Mol Sci 23 3927 (2022)
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