› 2p8p

X-ray diffraction
2.7Å resolution

Crystal structure of the HIV-1 Cross Neutralizing Monoclonal Antibody 2F5 in complex with gp41 Peptide LELDKWASLW[N-Ac]

Released:
DOI: 10.2210/pdb2p8p/pdb
PDB entry 2p8p coloured by chain, front view.
PDB entry 2p8p coloured by chain, side view.
PDB entry 2p8p coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structural details of HIV-1 recognition by the broadly neutralizing monoclonal antibody 2F5: epitope conformation, antigen-recognition loop mobility, and anion-binding site.
Julien JP, Bryson S, Nieva JL, Pai EF
J Mol Biol 384 377-92 (2008)
PMID: 18824005

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:
Structure domains:

Structure analysis Details

Assembly composition:
hetero trimer (preferred)
PDBe Complex ID:
PDB-CPX-211602 (preferred)
Entry contents:
3 distinct polypeptide molecules
Macromolecules (3 distinct):
nmAb 2F5, light chain Chain: A
Molecule details ›
Chain: A
Length: 214 amino acids
Theoretical weight: 23.36 KDa
Source organism: Homo sapiens
Structure domains: Immunoglobulins
nmAb 2F5, heavy chain Chain: B
Molecule details ›
Chain: B
Length: 235 amino acids
Theoretical weight: 24.99 KDa
Source organism: Homo sapiens
Structure domains: Immunoglobulins
gp41 peptide Chain: C
Molecule details ›
Chain: C
Length: 11 amino acids
Theoretical weight: 1.26 KDa

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU RU300
Spacegroup: P212121
Unit cell:
a: 58.5Å b: 64.3Å c: 178.2Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.238 0.238 0.266

Quick links

Citations

9 review citations

Structural insights into key sites of vulnerability on HIV-1 Env and influenza HA.
Julien et al. (2012)
8 more

2 mentions without citation

Computer-Aided Approaches for Targeting HIVgp41.
Allen et al. (2012)
1 more