X-ray diffraction
1.82Å resolution

Crystal structure of the serine/threonine phosphatase domain of human PPM1B


Function and Biology Details

Reaction catalysed:
[a protein]-serine/threonine phosphate + H(2)O = [a protein]-serine/threonine + phosphate
Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
Protein phosphatase 1B Chains: A, B
Molecule details ›
Chains: A, B
Length: 307 amino acids
Theoretical weight: 34.31 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
  • Canonical: O75688 (Residues: 2-297; Coverage: 62%)
Gene names: PP2CB, PPM1B
Sequence domains: Protein phosphatase 2C
Structure domains: PPM-type phosphatase domain

Ligands and Environments

1 bound ligand:
1 modified residue:

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 31-ID
Spacegroup: P212121
Unit cell:
a: 52.399Å b: 92.315Å c: 118.713Å
α: 90° β: 90° γ: 90°
R R work R free
0.189 0.186 0.246
Expression system: Escherichia coli BL21(DE3)