2p6a

X-ray diffraction
3.4Å resolution

The structure of the Activin:Follistatin 315 complex

Released:

Function and Biology Details

Structure analysis Details

Assembly composition:
hetero pentamer (preferred)
Entry contents:
3 distinct polypeptide molecules
Macromolecules (3 distinct):
Inhibin beta A chain Chains: A, B
Molecule details ›
Chains: A, B
Length: 116 amino acids
Theoretical weight: 12.99 KDa
Source organism: Homo sapiens
Expression system: Cricetulus griseus
UniProt:
  • Canonical: P08476 (Residues: 311-426; Coverage: 29%)
Gene name: INHBA
Sequence domains: Transforming growth factor beta like domain
Structure domains: Cystine-knot cytokines
Follistatin Chains: C, D
Molecule details ›
Chains: C, D
Length: 315 amino acids
Theoretical weight: 34.8 KDa
Source organism: Homo sapiens
Expression system: Cricetulus griseus
UniProt:
  • Canonical: P19883 (Residues: 30-344; Coverage: 100%)
Gene name: FST
Sequence domains:
Structure domains:
probable fragment of follistatin Chain: E
Molecule details ›
Chain: E
Length: 10 amino acids
Theoretical weight: 729 Da

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 5ID-B
Spacegroup: P2221
Unit cell:
a: 104.641Å b: 106.584Å c: 87.568Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.225 0.223 0.324
Expression system: Cricetulus griseus