X-ray diffraction
2.75Å resolution

Crystal Structure of Dengue Methyltransferase in Complex with GpppG and S-Adenosyl-L-homocysteine


Function and Biology Details

Reactions catalysed:
NTP + H(2)O = NDP + phosphate
ATP + H(2)O = ADP + phosphate
Selective hydrolysis of -Xaa-Xaa-|-Yaa- bonds in which each of the Xaa can be either Arg or Lys and Yaa can be either Ser or Ala.
Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assemblies composition:
monomeric (preferred)
homo dimer
Entry contents:
1 distinct polypeptide molecule
type II methyltransferase Chain: A
Molecule details ›
Chain: A
Length: 305 amino acids
Theoretical weight: 34.4 KDa
Source organism: Dengue virus 2
Expression system: Escherichia coli
  • Canonical: Q20IJ2 (Residues: 2495-2787; Coverage: 9%)
Sequence domains: FtsJ-like methyltransferase
Structure domains: Vaccinia Virus protein VP39

Ligands and Environments

3 bound ligands:
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF BEAMLINE ID14-2
Spacegroup: P3121
Unit cell:
a: 111.502Å b: 111.502Å c: 56.534Å
α: 90° β: 90° γ: 120°
R R work R free
0.212 0.208 0.271
Expression system: Escherichia coli