› 2p27

X-ray diffraction
1.9Å resolution

Crystal Structure of Human Pyridoxal Phosphate Phosphatase with Mg2+ at 1.9 A resolution

Released:
DOI: 10.2210/pdb2p27/pdb
PDB entry 2p27 coloured by chain, front view.
PDB entry 2p27 coloured by chain, side view.
PDB entry 2p27 coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structural genomics of protein phosphatases.
Almo SC, Bonanno JB, Sauder JM, Emtage S, Dilorenzo TP, Malashkevich V, Wasserman SR, Swaminathan S, Eswaramoorthy S, Agarwal R, Kumaran D, Madegowda M, Ragumani S, Patskovsky Y, Alvarado J, Ramagopal UA, Faber-Barata J, Chance MR, Sali A, Fiser A, Zhang ZY, Lawrence DS, Burley SK
J Struct Funct Genomics 8 121-40 (2007)
PMID: 18058037

Function and Biology Details

Reactions catalysed: 
[a protein]-serine/threonine phosphate + H(2)O = [a protein]-serine/threonine + phosphate
Pyridoxal 5'-phosphate + H(2)O = pyridoxal + phosphate
Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-188517 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Chronophin Chain: A
Molecule details ›
Chain: A
Length: 306 amino acids
Theoretical weight: 33.14 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q96GD0 (Residues: 2-296; Coverage: 100%)
Gene names: CIN, PDXP, PLP, PLPP
Sequence domains:
Structure domains: HAD superfamily/HAD-like

Ligands and Environments

1 bound ligand:
Ligand MG 1 x MG
1 modified residue:
Ligand MSE 4 x MSE

Experiments and Validation Details

Entry percentile scores
X-ray source: NSLS BEAMLINE X29A
Spacegroup: P43212
Unit cell:
a: 54.245Å b: 54.245Å c: 213.182Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.213 0.211 0.25
Expression system: Escherichia coli

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Citations

24 review citations

Aiding and abetting roles of NOX oxidases in cellular transformation.
Block et al. (2012)
23 more

3 mentions without citation

Structural genomics of protein phosphatases.
Almo et al. (2007)
2 more