› 2p1t

X-ray diffraction
1.8Å resolution

Crystal structure of the ligand binding domain of the retinoid X receptor alpha in complex with 3-(2'-methoxy)-tetrahydronaphtyl cinnamic acid and a fragment of the coactivator TIF-2

Released:
DOI: 10.2210/pdb2p1t/pdb
PDB 2p1t coloured by chain and viewed from the front.
PDB 2p1t coloured by chain and viewed from the side.
PDB 2p1t coloured by chain and viewed from the top.
Source organism: Homo sapiens
Primary publication:
Modulators of the structural dynamics of the retinoid X receptor to reveal receptor function.
Nahoum V, Pérez E, Germain P, Rodríguez-Barrios F, Manzo F, Kammerer S, Lemaire G, Hirsch O, Royer CA, Gronemeyer H, de Lera AR, Bourguet W
Proc. Natl. Acad. Sci. U.S.A. 104 17323-8 (2007)
PMID: 17947383

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
hetero tetramer (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Retinoic acid receptor RXR-alpha Chain: A
Molecule details ›
Chain: A
Length: 240 amino acids
Theoretical weight: 26.86 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P19793 (Residues: 223-462; Coverage: 52%)
Gene names: NR2B1, RXRA
Sequence domains: Ligand-binding domain of nuclear hormone receptor
Structure domains: Retinoid X Receptor
Nuclear receptor coactivator 2 Chain: B
Molecule details ›
Chain: B
Length: 13 amino acids
Theoretical weight: 1.58 KDa
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
  • Canonical: Q15596 (Residues: 686-698; Coverage: 1%)
Gene names: BHLHE75, NCOA2, SRC2, TIF2

Ligands and Environments

1 bound ligand:
Ligand 3TN 1 x 3TN
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF BEAMLINE ID14-2
Spacegroup: P43212
Unit cell:
a: 64.15Å b: 64.15Å c: 112.692Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.198 0.197 0.218
Expression systems:
  • Escherichia coli BL21(DE3)
  • Not provided

Quick links

Citations

9 review citations

Retinoid X Receptor Antagonists.
Watanabe et al. (2018)
8 more

13 mentions without citation

The retinoid X receptors and their ligands.
Dawson et al. (2012)
12 more