› 2p1c

X-ray diffraction
2.45Å resolution

T. Brucei Farnesyl Diphosphate Synthase Complexed with Bisphosphonate BPH-210

Released:
DOI: 10.2210/pdb2p1c/pdb
PDB entry 2p1c coloured by chain, front view.
PDB entry 2p1c coloured by chain, side view.
PDB entry 2p1c coloured by chain, top view.
Source organism: Trypanosoma brucei
Primary publication:
Structures of a potent phenylalkyl bisphosphonate inhibitor bound to farnesyl and geranylgeranyl diphosphate synthases.
Cao R, Chen CK, Guo RT, Wang AH, Oldfield E
Proteins 73 431-9 (2008)
PMID: 18442135

Function and Biology Details

Reaction catalysed: 
Geranyl diphosphate + isopentenyl diphosphate = diphosphate + (2E,6E)-farnesyl diphosphate
Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-183122 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Farnesyl pyrophosphate synthase Chains: A, B
Molecule details ›
Chains: A, B
Length: 390 amino acids
Theoretical weight: 44.48 KDa
Source organism: Trypanosoma brucei
Expression system: Escherichia coli
UniProt:
  • Canonical: Q86C09 (Residues: 1-367; Coverage: 100%)
Sequence domains: Polyprenyl synthetase
Structure domains: Farnesyl Diphosphate Synthase

Ligands and Environments

4 bound ligands:
Ligand MG 6 x MG
Ligand ACT 3 x ACT
Ligand GG3 2 x GG3
Ligand BME 1 x BME
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 22-BM
Spacegroup: P3121
Unit cell:
a: 92.124Å b: 92.124Å c: 177.747Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.266 0.266 0.299
Expression system: Escherichia coli

Quick links

Citations

6 review citations

Human isoprenoid synthase enzymes as therapeutic targets.
Park et al. (2014)
5 more

7 mentions without citation

The Potential of Secondary Metabolites from Plants as Drugs or Leads against Protozoan Neglected Diseases-Part III: In-Silico Molecular Docking Investigations.
Ogungbe et al. (2016)
6 more