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Crystal structure of the Leishmania infantum glyoxalase II

Source organism: Leishmania infantum
Biochemical function: metal ion binding
Biological process: not assigned
Cellular component: not assigned

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EC 3.1.2.6: Hydroxyacylglutathione hydrolase

Reaction catalysed:
S-(2-hydroxyacyl)glutathione + H(2)O = glutathione + a 2-hydroxy carboxylate
Systematic name:
S-(2-hydroxyacyl)glutathione hydrolase
Alternative Name(s):
  • Acetoacetylglutathione hydrolase
  • Glyoxalase II
  • S-2-hydroxylacylglutathione hydrolase

GO terms

Biochemical function:
Biological process:
  • not assigned
Cellular component:
  • not assigned

Sequence family

Pfam Protein family (Pfam)
PF16123
Domain description: Hydroxyacylglutathione hydrolase C-terminus
Occurring in:
  1. Metallo-beta-lactamase domain-containing protein
The deposited structure of PDB entry 2p18 contains 1 copy of Pfam domain PF16123 (Hydroxyacylglutathione hydrolase C-terminus) in Metallo-beta-lactamase domain-containing protein. Showing 1 copy in chain A.

InterPro InterPro annotations
IPR036866
Domain description: Ribonuclease Z/Hydroxyacylglutathione hydrolase-like
Occurring in:
  1. Metallo-beta-lactamase domain-containing protein
IPR032282
Domain description: Hydroxyacylglutathione hydrolase, C-terminal domain
Occurring in:
  1. Metallo-beta-lactamase domain-containing protein
IPR001279
Domain description: Metallo-beta-lactamase
Occurring in:
  1. Metallo-beta-lactamase domain-containing protein
IPR035680
Domain description: Hydroxyacylglutathione hydrolase, MBL domain
Occurring in:
  1. Metallo-beta-lactamase domain-containing protein

Structure domain

CATH CATH domain
3.60.15.10
Class: Alpha Beta
Architecture: 4-Layer Sandwich
Topology: Metallo-beta-lactamase; Chain A
Homology: Ribonuclease Z/Hydroxyacylglutathione hydrolase-like
Occurring in:
  1. Metallo-beta-lactamase domain-containing protein
The deposited structure of PDB entry 2p18 contains 1 copy of CATH domain 3.60.15.10 (Metallo-beta-lactamase; Chain A) in Metallo-beta-lactamase domain-containing protein. Showing 1 copy in chain A.

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