2p18

X-ray diffraction
1.8Å resolution

Crystal structure of the Leishmania infantum glyoxalase II

Released:

Function and Biology Details

Reaction catalysed:
S-(2-hydroxyacyl)glutathione + H(2)O = glutathione + a 2-hydroxy carboxylate
Biochemical function:
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Putative glyoxalase II Chain: A
Molecule details ›
Chain: A
Length: 311 amino acids
Theoretical weight: 34.42 KDa
Source organism: Leishmania infantum
Expression system: Escherichia coli
UniProt:
  • Canonical: Q2PYN0 (Residues: 1-295; Coverage: 100%)
Gene name: LINJ.12.0200
Sequence domains: Hydroxyacylglutathione hydrolase C-terminus
Structure domains: Ribonuclease Z/Hydroxyacylglutathione hydrolase-like

Ligands and Environments

3 bound ligands:
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF BEAMLINE ID23-1
Spacegroup: C2221
Unit cell:
a: 66.705Å b: 88.989Å c: 85.864Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.246 0.171 0.196
Expression system: Escherichia coli