X-ray diffraction
2Å resolution

Crystal structure of Mycobacterium tuberculosis protein tyrosine phosphatase PtpB in complex with the specific inhibitor OMTS


Function and Biology Details

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
TYR_PHOSPHATASE_2 domain-containing protein Chains: A, B
Molecule details ›
Chains: A, B
Length: 296 amino acids
Theoretical weight: 32.37 KDa
Source organism: Mycobacterium tuberculosis H37Rv
Expression system: Escherichia coli
  • Canonical: P96830 (Residues: 1-276; Coverage: 100%)
Gene name: MT0162
Sequence domains: Tyrosine phosphatase family
Structure domains: Protein tyrosine phosphatase superfamily

Ligands and Environments

1 bound ligand:
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ALS BEAMLINE 8.3.1
Spacegroup: P212121
Unit cell:
a: 74.396Å b: 72.488Å c: 96.064Å
α: 90° β: 90° γ: 90°
R R work R free
0.192 0.189 0.249
Expression system: Escherichia coli