PDBe 2ow9

X-ray diffraction
1.74Å resolution

Crystal structure analysis of the MMP13 catalytic domain in complex with specific inhibitor

Released:

Function and Biology Details

Structure analysis Details

Assemblies composition:
monomeric (preferred)
homo tetramer
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Collagenase 3 Chains: A, B
Molecule details ›
Chains: A, B
Length: 170 amino acids
Theoretical weight: 19.07 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P45452 (Residues: 104-270; Coverage: 37%)
Gene name: MMP13
Sequence domains: Matrixin
Structure domains: Collagenase (Catalytic Domain)

Ligands and Environments


No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 17-ID
Spacegroup: C2
Unit cell:
a: 140.764Å b: 36.343Å c: 71.684Å
α: 90° β: 93.53° γ: 90°
R-values:
R R work R free
0.168 0.167 0.191
Expression system: Escherichia coli