X-ray diffraction
2.8Å resolution

Glycogen synthase kinase-3 beta in complex with bis-(indole)maleimide pyridinophane inhibitor


Function and Biology Details

Reactions catalysed:
ATP + a protein = ADP + a phosphoprotein
ATP + [tau protein] = ADP + [tau protein] phosphate
Biochemical function:
Biological process:
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
Glycogen synthase kinase-3 beta Chains: A, B
Molecule details ›
Chains: A, B
Length: 352 amino acids
Theoretical weight: 40.08 KDa
Source organism: Homo sapiens
Expression system: Not provided
  • Canonical: P49841 (Residues: 35-386; Coverage: 84%)
Gene name: GSK3B
Sequence domains: Protein kinase domain
Structure domains:

Ligands and Environments

1 bound ligand:

1 modified residue:

Experiments and Validation Details

Entry percentile scores
X-ray source: SLS BEAMLINE X10SA
Spacegroup: P21
Unit cell:
a: 69.472Å b: 117.329Å c: 69.461Å
α: 90° β: 103.22° γ: 90°
R R work R free
0.248 0.246 0.295
Expression system: Not provided