Function and Biology

Crystal structure of the MAP kinase binding domain of MKP5

Source organism: Homo sapiens
Biochemical function: not assigned
Biological process: not assigned
Cellular component: not assigned

EC 3.1.3.48: Protein-tyrosine-phosphatase

Reaction catalysed:
Protein tyrosine phosphate + H(2)O = protein tyrosine + phosphate
Systematic name:
Protein-tyrosine-phosphate phosphohydrolase
Alternative Name(s):
  • (Phosphotyrosine)protein phosphatase
  • PPT-phosphatase
  • PTP-phosphatase
  • PTPase
  • Phosphoprotein phosphatase (phosphotyrosine)
  • Phosphotyrosine histone phosphatase
  • Phosphotyrosine phosphatase
  • Phosphotyrosine protein phosphatase
  • Phosphotyrosylprotein phosphatase
  • Protein phosphotyrosine phosphatase
  • Tyrosine O-phosphate phosphatase
  • Tyrosylprotein phosphatase

EC 3.1.3.16: Protein-serine/threonine phosphatase

Reaction catalysed:
[a protein]-serine/threonine phosphate + H(2)O = [a protein]-serine/threonine + phosphate
Systematic name:
Phosphoprotein phosphohydrolase
Alternative Name(s):
  • 3-hydroxy 3-methylglutaryl coenzymeA reductase phosphatase
  • Aspergillus awamori acid protein phosphatase
  • BCKDH phosphatase
  • Branched-chain alpha-keto acid dehydrogenase phosphatase
  • Calcineurin
  • Casein phosphatase
  • HMG-CoA reductase phosphatase
  • Phosphatase 2A
  • Phosphatase 2B
  • Phosphatase C-II
  • Phosphatase H-II
  • Phosphatase I
  • Phosphatase IB
  • Phosphatase II
  • Phosphatase III
  • Phosphatase IV
  • Phosphatase SP
  • Phosphoprotein phosphatase
  • Phosphopyruvate dehydrogenase phosphatase
  • Phosphospectrin phosphatase
  • Polycation modulated (PCM-) phosphatase
  • Protein D phosphatase
  • Protein phosphatase
  • Protein phosphatase-1
  • Protein phosphatase-2A
  • Protein phosphatase-2B
  • Protein phosphatase-2C
  • Serine/threonine specific protein phosphatase

GO terms

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Sequence family

Pfam Protein family (Pfam)
PF00581
Domain description: Rhodanese-like domain
Occurring in:
  1. Dual specificity protein phosphatase 10
The deposited structure of PDB entry 2ouc contains 2 copies of Pfam domain PF00581 (Rhodanese-like domain) in Dual specificity protein phosphatase 10. Showing 1 copy in chain A.

InterPro InterPro annotations
IPR001763
Domain description: Rhodanese-like domain
Occurring in:
  1. Dual specificity protein phosphatase 10
IPR036873
Domain description: Rhodanese-like domain superfamily
Occurring in:
  1. Dual specificity protein phosphatase 10

Structure domain

CATH CATH domain
3.40.250.10
Class: Alpha Beta
Architecture: 3-Layer(aba) Sandwich
Topology: Oxidized Rhodanese; domain 1
Homology: Rhodanese-like domain
Occurring in:
  1. Dual specificity protein phosphatase 10
The deposited structure of PDB entry 2ouc contains 2 copies of CATH domain 3.40.250.10 (Oxidized Rhodanese; domain 1) in Dual specificity protein phosphatase 10. Showing 1 copy in chain A.