X-ray diffraction
1.61Å resolution

Crystal structure of DESC1, a new member of the type II transmembrane serine proteinases family


Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
Transmembrane protease serine 11E catalytic chain Chain: A
Molecule details ›
Chain: A
Length: 232 amino acids
Theoretical weight: 25.52 KDa
Source organism: Homo sapiens
Expression system: Komagataella pastoris
  • Canonical: Q9UL52 (Residues: 192-423; Coverage: 55%)
Gene names: DESC1, TMPRSS11E, TMPRSS11E2, UNQ742/PRO1461
Sequence domains: Trypsin
Structure domains: Trypsin-like serine proteases

Ligands and Environments

1 bound ligand:
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU
Unit cell:
a: 47.9Å b: 70.2Å c: 80.2Å
α: 90° β: 90° γ: 90°
R R work R free
0.21 0.21 0.224
Expression system: Komagataella pastoris