› 2oq5

X-ray diffraction
1.61Å resolution

Crystal structure of DESC1, a new member of the type II transmembrane serine proteinases family

Released:
DOI: 10.2210/pdb2oq5/pdb
PDB entry 2oq5 coloured by chain, front view.
PDB entry 2oq5 coloured by chain, side view.
PDB entry 2oq5 coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Crystal structure of the catalytic domain of DESC1, a new member of the type II transmembrane serine proteinase family.
Kyrieleis OJ, Huber R, Ong E, Oehler R, Hunter M, Madison EL, Jacob U
FEBS J 274 2148-60 (2007)
PMID: 17388811

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-193912 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Transmembrane protease serine 11E catalytic chain Chain: A
Molecule details ›
Chain: A
Length: 232 amino acids
Theoretical weight: 25.52 KDa
Source organism: Homo sapiens
Expression system: Komagataella pastoris
UniProt:
  • Canonical: Q9UL52 (Residues: 192-423; Coverage: 55%)
Gene names: DESC1, TMPRSS11E, TMPRSS11E2, UNQ742/PRO1461
Sequence domains: Trypsin
Structure domains: Trypsin-like serine proteases

Ligands and Environments

1 bound ligand:
Ligand BEN 1 x BEN
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU
Unit cell:
a: 47.9Å b: 70.2Å c: 80.2Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.21 0.21 0.224
Expression system: Komagataella pastoris

Quick links

Citations

6 review citations

Membrane-anchored serine proteases in health and disease.
Antalis et al. (2011)
5 more

27 mentions without citation

A review on drug repurposing applicable to COVID-19.
Dotolo et al. (2021)
26 more