PDBe 2ome

X-ray diffraction
2.8Å resolution

Crystal structure of human CTBP2 dehydrogenase complexed with NAD(H)

Released:
Source organism: Homo sapiens
Entry authors: Pilka ES, Guo K, Rojkova A, Debreczeni JE, Kavanagh KL, von Delft F, Arrowsmith CH, Weigelt J, Edwards A, Sundstrom M, Oppermann U, Structural Genomics Consortium (SGC)

Function and Biology Details

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
C-terminal-binding protein 2 Chains: A, B, C, D, E, F, G, H
Molecule details ›
Chains: A, B, C, D, E, F, G, H
Length: 336 amino acids
Theoretical weight: 37.27 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P56545 (Residues: 31-364; Coverage: 75%)
Gene name: CTBP2
Sequence domains:
Structure domains: NAD(P)-binding Rossmann-like Domain

Ligands and Environments

1 bound ligand:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SLS BEAMLINE X10SA
Spacegroup: P21
Unit cell:
a: 87.754Å b: 141.574Å c: 138.215Å
α: 90° β: 98.93° γ: 90°
R-values:
R R work R free
0.21 0.207 0.257
Expression system: Escherichia coli BL21(DE3)