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Structure of human insulin in presence of thiocyanate at pH 6.5

X-ray diffraction
1.97Å resolution
PDB entry 2om1 coloured by chain, front view.
PDB entry 2om1 coloured by chain, side view.
PDB entry 2om1 coloured by chain, top view.
Source organism: Homo sapiens
Assembly composition:
hetero dodecamer (preferred)
Entry contents: 2 distinct polypeptide molecules

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Assemblies

Assembly 1
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Assembly Name: Insulin A chain
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Multimeric state: hetero dodecamer
Accessible surface area: 12531.89 Å2
Buried surface area: 20282.17 Å2
Dissociation area: 5,602.03 Å2
Dissociation energy (ΔGdiss): 60.5 kcal/mol
Dissociation entropy (TΔSdiss): 53.03 kcal/mol
Symmetry number: 6
PDBe Complex ID: PDB-CPX-134235
Assembly 2 (preferred)
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Assembly Name: Insulin A chain
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Multimeric state: hetero dodecamer
Accessible surface area: 12406.14 Å2
Buried surface area: 20800.73 Å2
Dissociation area: 5,572.99 Å2
Dissociation energy (ΔGdiss): 58.74 kcal/mol
Dissociation entropy (TΔSdiss): 53.02 kcal/mol
Symmetry number: 6
PDBe Complex ID: PDB-CPX-134235
Assembly 3
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Assembly Name: Insulin A chain
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Multimeric state: hetero dodecamer
Accessible surface area: 12194.65 Å2
Buried surface area: 20350.17 Å2
Dissociation area: 5,471.99 Å2
Dissociation energy (ΔGdiss): 60.76 kcal/mol
Dissociation entropy (TΔSdiss): 52.93 kcal/mol
Symmetry number: 6
PDBe Complex ID: PDB-CPX-134235

Macromolecules

Insulin A chain
Chains: 1, 3, A, C, E, G, I, K, Q, S, U, X, a, c, e, g, i, k
Length: 21 amino acids
Theoretical weight: 2.38 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: P01308 (Residues: 90-110; Coverage: 24%)
Gene name: INS
InterPro:
Insulin A chain in PDB entry 2om1, assembly 2, front view.
Insulin A chain in PDB entry 2om1, assembly 2, side view.
Insulin A chain in PDB entry 2om1, assembly 2, top view.
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Insulin B chain
Chains: 2, 4, B, D, F, H, J, L, R, T, V, Y, b, d, f, h, j, l
Length: 30 amino acids
Theoretical weight: 3.43 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: P01308 (Residues: 25-54; Coverage: 35%)
Gene name: INS
Pfam: Insulin/IGF/Relaxin family
InterPro:
SCOP: Isolated insulin B-chain
Insulin B chain in PDB entry 2om1, assembly 2, front view.
Insulin B chain in PDB entry 2om1, assembly 2, side view.
Insulin B chain in PDB entry 2om1, assembly 2, top view.
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