X-ray diffraction
2.3Å resolution

The X-ray crystal structure of the 65kDa isoform of Glutamic Acid Decarboxylase (GAD65)


Function and Biology Details

Reaction catalysed:
L-glutamate = 4-aminobutanoate + CO(2)
Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Entry contents:
1 distinct polypeptide molecule
Glutamate decarboxylase 2 Chain: A
Molecule details ›
Chain: A
Length: 497 amino acids
Theoretical weight: 56.78 KDa
Source organism: Homo sapiens
Expression system: Saccharomyces cerevisiae
  • Canonical: Q05329 (Residues: 88-584; Coverage: 85%)
Gene names: GAD2, GAD65
Sequence domains: Pyridoxal-dependent decarboxylase conserved domain
Structure domains:

Ligands and Environments

2 bound ligands:
1 modified residue:

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 17-ID
Spacegroup: C2221
Unit cell:
a: 78.251Å b: 99.057Å c: 120.009Å
α: 90° β: 90° γ: 90°
R R work R free
0.2 0.196 0.256
Expression system: Saccharomyces cerevisiae